Classification of Molecular Biomarkers

  • Ankeet Shah Duke Cancer Institute
  • Dominic C. Grimberg
  • Brant A. Inman
Keywords: urologic oncology, tissues, body fluids, tissue fixation, cryopreservation, nucleic acids, biomarker


 A “biomarker” is any measurable characteristic that indicates the presence or absence of disease or the biological response to a stimulus, typically an exposure or intervention. The FDA-NIH Biomarker Working Group has produced a document called Biomarkers, EndpointS and other Tools (BEST), which defines 7 categories of biomarkers according to their clinical usage: susceptibility and risk, diagnostic, monitoring, prognostic, predictive, pharmacodynamic and treatment response, and safety. We approach the classification of biomarkers in 2 additional ways: their bodily source and their measurement type. In the context of their use in genitourinary malignancy, we also consider factors that influence their use and reliability in clinical and research applications.

How to Cite
Shah, A., Grimberg, D. C., & Inman, B. A. (2020). Classification of Molecular Biomarkers. Société Internationale d’Urologie Journal, 1(1), 8-15. Retrieved from
Molecular Biomarkers in Urologic Oncology