One-Year Outcomes of the ROBUST II Study Evaluating the Use of a Drug-Coated Balloon for Treatment of Urethral Stricture
Objectives: To report 1-year results of the ROBUST II study investigating the safety and efficacy of a paclitaxelcoated
balloon for the treatment of recurrent urethral strictures.
Methods: Subjects were adult men with a single anterior urethral stricture ≤ 3 cm in length and at least 2 prior
stricture treatments. After treatment with the Optilume urethral drug-coated balloon (DCB), subjects were followed
through 1 year. The primary safety endpoint was the rate of treatment-related serious complications at 90 days postprocedure.
Efficacy outcomes included symptomatic assessments, erectile function measured using the International
Index of Erectile Function (IIEF), Qmax, and anatomic success.
Results: Sixteen men with an average of 4.1 prior dilations were treated with the DCB. Anatomic success was
achieved at 6 months in 73%. Average IPSS improved from 18.4 to 6.0 at 1 year (P < 0.001). Qmax improved from
6.9 mL/sec to 20.8 mL/sec (P < 0.001). There was no change in IIEF. Four subjects received additional treatment within
1 year. There were no treatment-related serious complications.
Conclusions: Short-term follow-up of men with urethral stricture treated with the Optilume DCB showed
durable anatomic results at 6 months and sustained symptomatic improvement through 1 year. Treatment with
the device was safe.
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