The Efficacy and Safety of a Conservative Management Approach to Radiation-Induced Male Urethral Strictures in Elderly Patients With Comorbidities

  • Alexander T. Rozanski
  • Matthew J. Moynihan
  • Lawrence T. Zhang
  • Alexandra C. Muise
  • Daniel D. Holst
  • Steven A. Copacino
  • Leonard N. Zinman
  • Jill C. Buckley
  • Alex J. Vanni
Keywords: Radiotherapy, urethral stricture, dilation, intermittent catheterization

Abstract

Objectives: To assess the outcomes of a conservative management approach to radiation-induced urethral stricture
disease (R-USD) in an elderly population with comorbidities.
Methods: Patients with R-USD managed with endoscopic procedures and/or clean intermittent catheterization
(CIC) between 2007 and 2019 were included. Patients were excluded if they had an obliterative stricture, prior
urethral reconstruction/urinary diversion surgery, or < 3 months follow-up. Primary outcome measures were
urinary tract infection (UTI), acute urinary retention (AUR), serum creatinine, uroflowmetry/post-void residual,
and urinary incontinence (UI). Failure was defined as progression to reconstructive surgery or permanent indwelling
catheterization.
Results: Ninety-one men were analyzed with a median follow-up of 15.0 months (IQR 8.9 to 37.9). Median age
was 75.4 years (IQR 70.0 to 80.0), body mass index was 26.5 kg/m2 (IQR 24.8 to 30.3), and Charlson comorbidity
index was 6 (IQR 5 to 8). Median stricture length was 2.0 cm (IQR 2.0 to 3.0). Stricture location was bulbar (12%),
bulbomembranous (75%), and prostatic (13%). A total of 90% underwent dilation, and 44% underwent direct visual
internal urethrotomy (DVIU). For those that underwent these procedures, median number of dilations and DVIUs
per patient was 2 (IQR 1 to 5) and 1 (IQR 1 to 3), respectively. Forty percent used CIC. Thirty-four percent developed a
UTI, and 15% had an AUR episode requiring urgent treatment. Creatinine values, uroflowmetry measurements, and
UI rates remained stable. Eighty percent avoided reconstructive surgery or indwelling catheterization.
Conclusion: Most elderly patients with comorbidities with R-USD appear to be effectively managed in the shortterm
with conservative strategies. Close observation is warranted because of the risk of UTIs and AUR. The potential
long-term consequences of repetitive conservative interventions must be considered.

Published
2022-01-04
How to Cite
Rozanski, A. T., Moynihan, M. J., Zhang, L. T., Muise, A. C., Holst, D. D., Copacino, S. A., Zinman, L. N., Buckley, J. C., & Vanni, A. J. (2022). The Efficacy and Safety of a Conservative Management Approach to Radiation-Induced Male Urethral Strictures in Elderly Patients With Comorbidities. Société Internationale d’Urologie Journal, 3(1), 14-20. https://doi.org/10.48083/XFYL6260
Section
Original Research